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Single Dose of Psilocybin Can Repair the Loss of Neural Connections Resulting from Depression – Yale Study Confirms

For the past decade, psychedelics have received an increase in attention from the right places, such as Health Canada and the FDA. Research into how they can help improve the physical and mental health of millions of people is currently underway in various parts of the globe. Psilocybin, a compound found in magic mushrooms, has been classified as a ‘breakthrough therapy’ by the FDA. It has shown great promise in the treatment and management of depression and stress.

According to a new study by Yale researchers, psilocybin can repair the loss of neural connection resulting from depression and stress. While there have been numerous studies indicating the same, this is the first that explains how the whole process happens. Depression and stress damage the brain’s connections over time, interfering with signal transmission. A single dose of psilocybin reverses the damage and brings the cells to perfection.

According to the scientists, psilocybin caused a 10% increase in neural connection and increased their strength and size by 10%, making them better and more effective in accomplishing their tasks.

neural connections

Details of the Study
Yale researchers conducted a study on mice to investigate the effects of psilocybin on damaged neural connections. The mice were given a single dose of the psilocybin, and their dendritic spines were observed under a high-resolution microscope. Within 24 hours, the researchers noted a significant change in the condition, size, and the number of dendritic spines.

What are dendritic spines? They are tiny protrusions that aid in the transmission of neural signals in the brain. They also play the secondary role of synaptic strength storage. When an individual goes through depression or chronic stress, the dendritic spines are damaged.

After a month, the researchers noted that the changes in the condition of the dendritic spines were still there. This showed that a single dose of psilocybin has long-lasting, positive effects on damaged neural connections.

 

Take Away
Psychedelic trips induced by psilocybin may offer life-changing effects to patients suffering from depression and chronic stress. This is positive news, especially when considering that millions of individuals are severely affected by these two conditions. Finding a permanent solution to a global issue is always something to celebrate.

Magic mushrooms have for a long time being associated with a myriad of mental and physical benefits. This is the first study that illustrates precisely how this happens. Although the study was conducted on mice, it offers hope as an effective treatment for neural damage in humans. There is a need to conduct more research to validate this study’s findings.

 

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